Collagen synthesis and collagenase activity of cryopreserved heart valves

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From the Departments of Cardiovascular

Collagen synthesis and collagenase activity of cryopreserved heart valves

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Collagen composition of normal and myxomatous human mitral heart valves.

The collagens were studied in 13 normal and 19 myxomatous human mitral valves. The collagens of the valve were completely solubilized by using a method consisting of guanidinium chloride extraction, limited pepsin digestions and CNBr cleavage of the residue. The normal valves contained 74% type I, 24% type III and 2% type V collagen. The type I and type III collagens had similar solubility patt...

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Collagen and Collagenase

That rheumatic fever generally attacks children and rheumatoid arthritis usually occurs in adults may be due to an alteration in the target organ (collagen plus ground substance) with age. Perhaps young, growing collagen is more susceptible to the stimuli producing rheumatic fever, whilst the more metabolically inert adult collagen responds with rheumatoid change to factors as yet unknown. One ...

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comparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.

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[Collagen synthesis and heart failure].

Little is known about collagen metabolism in heart failure, with or without left ventricular systolic dysfunction. We studied serum concentrations of the carboxy-terminal propeptide of procollagen type I (PIP), a marker of collagen type-I synthesis, and of the carboxy-terminal telopeptide of collagen type I (ICTP), a marker of collagen type-I degradation, in 70 patients admitted for heart failu...

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ژورنال

عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery

سال: 2001

ISSN: 0022-5223

DOI: 10.1067/mtc.2001.115421